Glimepiride is a long-acting sulfonylurea used to treat type 2 diabetes. It lowers blood glucose by stimulating the release of insulin from the pancreas. It is often used in combination with other anti-diabetic medications or insulin.

Gliclazide is a sulfonylurea medication primarily used to treat type 2 diabetes. It helps lower blood sugar levels by stimulating the pancreas to produce more insulin. It is typically prescribed when diet and exercise alone are insufficient to control blood glucose.